World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF SUSTAINED RELEASE BUCCAL PATCHES OF PROPRANOLOL HYDROCHLORIDE USING NEEM GUM

Patel Fayam*, Juber Khan, Kazi Usama, Patel Raihan, Deshmukh Rehan, G. J. Khan

ABSTRACT

Mucoadhesive patch releasing the drug in the oral cavity at predetermined rate may present advantages over traditional dosage forms such as tablets, gels and solutions. The present study was focused on preparation and evaluation of mucoadhesive buccal patches for the controlled systemic delivery of Propranolol Hydrochloride using neem gum and hydroxypropyl methylcellulose (K100 M) as polymers in various proportions and combinations by solvent casting technique to avoid first pass hepatic metabolism. Propylene Glycol was used as plasticizer. The developed patches were evaluated for the physicochemical, mechanical and drug release characteristics like weight variation, thickness, folding endurance, tensile strength, swelling study, surface pH, mucoadhesive strength, in vitro residence time, drug content uniformity and drug release. The patches showed desired mechanical and physicochemical properties to withstand environment of oral cavity. The in-vitro release study showed that patches could deliver drug to the oral mucosa for a period of 8 h. the patches exhibited adequate stability when tested under accelerated conditions.

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