World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, Scholar Article Journal Index (SAJI), International Scientific Indexing ( ISI ), Scope Database, 

Abstract

A STUDY ON FORMULATION AND EVALUATION OF MICROSPHERES OF BENAZEPRIL ANTI HYPERTENSIVE DRUG

Preethi Fernandiz, Suresh N.*, Kerryn Joseph A. D. Silva and S. Srinivasan

ABSTRACT

Benazepril HCl is an ACE inhibitor which is used in treatment of high blood pressure. Microspheres of Benazepril HCl were prepared using Chitosan and Xanthan gum by solvent evaporation technique. Compatibility study was carried out by using FTIR and results showed that there was no significant interaction between drug and excipients. Microspheres thus obtained were found to be pale yellow in color and showed free flowing character. Micromeritic studies showed that prepared microspores showed excellent to good flow properties. The Scanning electron microscopy results indicate that microspheres are of smooth and spherical in shape. Particle size was performed by using optical microscope and particle sizes are found in the range 152.8±8.35 to 276.2±5.47?m and particle size depends up on the concentration of Xanthan gum i.e. formulation containing higher concentration of Xanthan are larger size when compared to Chitosan containing batches. Entrapment efficiency results showed that formulation F10 containing 1:9 ratio of Chitosan: Xanthan gum showed highest percentage of entrapment (95.90%) and showed 59.74% of drug loading. In-vitro drug release showed decreases as concentration of Xanthan gum increases the dissolution profile of Benazepril HCl from prepared formulation. Formulation F2 containing 9:1 ratio of Chitosan: Xanthan gum showed 94.86% of drug release at the end of 12 hours. Short term stability study showed that prepared Benazepril microsphere formulation was physicochemically stable throughout stability period. The study has been conclude that microspheres offer a practical and suitable approach to prepare controlled release dosage form of Benazepril HCl with natural occurring gums like Chitosan and Xanthan gum.

[Full Text Article]

BEST PAPER AWARDS

World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here