World Journal of
Pharmaceutical and Life Sciences

A STUDY ON FORMULATION AND EVALUATION OF MICROSPHERES OF BENAZEPRIL ANTI HYPERTENSIVE DRUG

Preethi Fernandiz, Suresh N.*, Kerryn Joseph A. D. Silva and S. Srinivasan

ABSTRACT

Benazepril HCl is an ACE inhibitor which is used in treatment of high blood pressure. Microspheres of Benazepril HCl were prepared using Chitosan and Xanthan gum by solvent evaporation technique. Compatibility study was carried out by using FTIR and results showed that there was no significant interaction between drug and excipients. Microspheres thus obtained were found to be pale yellow in color and showed free flowing character. Micromeritic studies showed that prepared microspores showed excellent to good flow properties. The Scanning electron microscopy results indicate that microspheres are of smooth and spherical in shape. Particle size was performed by using optical microscope and particle sizes are found in the range 152.8±8.35 to 276.2±5.47?m and particle size depends up on the concentration of Xanthan gum i.e. formulation containing higher concentration of Xanthan are larger size when compared to Chitosan containing batches. Entrapment efficiency results showed that formulation F10 containing 1:9 ratio of Chitosan: Xanthan gum showed highest percentage of entrapment (95.90%) and showed 59.74% of drug loading. In-vitro drug release showed decreases as concentration of Xanthan gum increases the dissolution profile of Benazepril HCl from prepared formulation. Formulation F2 containing 9:1 ratio of Chitosan: Xanthan gum showed 94.86% of drug release at the end of 12 hours. Short term stability study showed that prepared Benazepril microsphere formulation was physicochemically stable throughout stability period. The study has been conclude that microspheres offer a practical and suitable approach to prepare controlled release dosage form of Benazepril HCl with natural occurring gums like Chitosan and Xanthan gum.

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