World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ANTIDEPRESSANT AND ANTIOXIDANT ACTIVITY OF ETHANOLIC POLYHERBAL EXTRACT USING ANIMAL MODEL

Sonali S. Gadiya and *Pradnya N. Jagtap

ABSTRACT

The present study was undertaken to evaluate the antioxidant and antidepressant activity of ethanolic Polyherbal extract. The ethanolic extracts were prepared by using leaves of Bacopa monnieri and fruits of Terminalia chebula by the maceration and percolation extraction process. Drugs were administered orally as per mg/kg body weight, one time for seven days. Antidepressant activity evaluated by force swim test and antioxidant activity by DPPH assay. The force swim test showed remarkable antidepressant activity at 250mg/kg in combination of BM and TC showing decrease in immobility time. Antioxidant activity by DPPH showing Radical Scavenging Activity of 94.40385% at 50?g/ml and IC50 of 38.8614 ?g/ml.

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