World Journal of
Pharmaceutical and Life Sciences

CURCUMIN AS A POTENTIAL BIOACTIVE HOLISTIC UNIT FROM RHIZOME

Soumya Roy, Arpita Biswas & Prof. Dr. Dhrubo Jyoti Sen*

ABSTRACT

Turmeric is a curry spice that originated from India, which has attracted great interest in recent decades because it contains bioactive curcuminoids Curcumin. In turmeric two other curcuminoids occur in lesser amounts namely, desmethoxycurcumin (DMC) and bis-desmethoxycurcumin (BDMC). Curcumin exerts a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic, immune modulating, metabolism regulating effects. In spite of its benefit on inflammatory and antioxidant mechanisms, one of the major problems with ingesting curcumin by itself is its poor bioavailability which caused primarily due to poor absorption, rapid metabolism, and rapid elimination. Several strategies are been adopted to increase curcumin’s bioavailability by addressing these various mechanisms. Most of them have been developed to block the metabolic pathway, increasing serum concentrations of curcumin in order to increase its bioavailability. For example: Piperine, Cyclodextrin, Liposomes, Phosphatidylcholine phytosome complex, di glutaric acid used as bioavailability enhancer by which can provide >100 folds better bioavailability than unformulated curcumin. How curcumin reacts with the body, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review.

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