World Journal of
Pharmaceutical and Life Sciences

URIC ACID IS ASSOCIATED WITH FUTURE ATRIAL FIBRILLATION: A 09-YEAR FOLLOW-UP OF 631 MEN AND WOMEN—STUDY AT TERTIARY CARE HOSPITAL FROM NORTH INDIA

Premshanker Singh*, MS Siddique, Ajay Misra, Devendra Kumar and Manoj Kumar

ABSTRACT

The aim of this study was to investigate the association between baseline Serum Uric Acid(SUA) and Atrial Fibrillation(AF) at single center tertiary care hospital from North India A total of 631 men and women from north India reporting to Medical OPD (MOPD)and Medical IPD(MIPD) of UP University of Medical Sciences, India. The mean age at baseline was 60 years. Information on angina, myocardial infarction, diabetes, anti-hypertensive and diuretic treatment, physical activity, smoking and alcohol, and measurements of height, weight, blood pressure, SUA, total cholesterol, and high density lipoprotein-cholesterol were obtained at baseline. The outcome measure was first-ever AF, documented on an electrocardiogram. We identified 57 cases of incident AF. In multivariable Cox proportional hazards regression analysis adjusted for cardiovascular risk factors and concomitant diseases, SUA was associated with AF in both sexes. Hazard ratio per 1 SD increase in SUA (91 ?mol/L) was 1.40 [95% confidence intervals (CI), 1.14–1.72] in women and 1.17 (95% CI, 1.02–1.36) in men. The upper quartile of SUA conferred a 76% increased risk for AF in women and 49% in men as compared with the lowest quartile ? The association between SUA levels and AF remained when adjusted for factors known to predispose for AF, such as cardiovascular disease, diabetes, metabolic factors (body mass index, lipids) or blood pressure, and the association was non-significantly stronger in women.

[Full Text Article]   [Download Certificate]