World Journal of
Pharmaceutical and Life Sciences

FATTY LIVER DISEASE IN TYPE 2 DIABETES AMONG SAMPLE OF IRAQI PATIENTS

Dr. Ali Sadiq M. Altamemi*

ABSTRACT

Objective: To assess the prevalence of non-alcoholic fatty liver disease in type II diabetes mellitus patients. Study Design: A Prospective cross-sectional Study. Place and Duration: Department of Medicine in Al-Yarmouk teaching hospital Baghdad, from 1st September 2020 to 1st March 2021. Methodology: Patients presenting with diabetes mellitus type II were divided into two groups based on the presence or absence of non-alcoholic fatty liver disease depending on abdominal ultrasound examination. Age, gender, body mass index, presence of hypertension, plasma aspartate aminotransferase, plasma alanine aminotransferase, plasma alkaline phosphatase, plasma gama glutamyl transferase, serum albumin, plasma cholesterol, plasma triglycerides, plasma low density lipoprotein, plasma high density lipoprotein and glycosylated haemoglobin HbA1c were the variables calculated. Results: Out Of 100 patients with T2DM, 52 patients (52%) were found to have changes of fatty liver disease in abdominal ultrasonography examination. The mean age of fatty liver group was 54.58±7.42 year and that of non-fatty liver group was 51.33± 9.69 year. The mean BMI of fatty liver group was 27.54±3.17 and that of non-fatty liver group was 24.58± 1.60. The mean HbA1c of fatty liver group was 8.97±0.777 and that of non-fatty liver group 7.37± 0.744.The mean serum bilirubin of fatty liver group was 1.08±0.255 and that of non-fatty liver group was 0.850±0.185 .The mean AST of fatty liver group was 42.35±5.691 and that of non-fatty liver group was 31.417± 3.426.The mean ALT of fatty liver group was 42.19±11.472 and that of non-fatty liver group was 32.08± 6.283.The mean ALP of fatty liver group was 139.65±34.325 and that of non-fatty liver group was 143.5± 52.625.The mean GGT of fatty liver group was 22.65±12.15 and that of non-fatty liver group was19.58± 9.35.The mean total cholesterol of fatty liver group was 210.115± 21.406 and that of non- fatty liver group was 175.5± 8.570.The mean total TG of fatty liver group was 201.65 ± 32.75 and that of non-fatty liver group 139± 23.4).The mean total HDL of fatty liver group was 39.154 and that of non-fatty liver group was 44.333.The mean LDL of fatty liver group was 117.731 and that of non-fatty liver group was 93.667. Conclusion: NAFLD is highly prevalent among patients with T2DM. Overweight or obesity, abnormal cholesterol levels and poor glycaemic control were significantly associated with NAFLD. Keywords: Non-alcoholic fatty liver disease, Diabetes mellitus, Prevalence.

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