World Journal of
Pharmaceutical and Life Sciences

CO-RRELATION OF DYSLIPIDEMIA WITH HYPERTENSION AND ITS CARDIAC OUTCOME-STUDY AT TERTIARY CARE HOSPITAL FROM CENTRAL INDIA

Premshanker Singh*, Ritu Karoli and Mridu Singh

ABSTRACT

Dyslipidemia and hypertension are the two widely recognized independent key risk factors for development of coronary vascular disorders (CVD). Therefore, Dyslipidemia and hypertension can serve as an easy clinical approach to know persons at greater risk and timely interference directed to decrease CVD events. Aim of study was to know correlation between dyslipidemia and hypertension and its cardiac outcome in a tertiary care hospital from central india. The present study was a prospective study conducted in the department of General Medicine in a tertiary care hospital at Lucknow, India-226010 over the period of two years from June 2017 to June2019. A total of HTN patients and 100 non hypertensive controls were recruited for the study. The patients were in the range of 35-75 years age group. Both known hypertensive patients who were on treatment for a varying period of time and newly diagnosed hypertensive patients were included in the study. The hypertensive and healthy controls were selected to the study by systematic random sampling. A structured and validated designed case report form (CRF) was used for data collection. The blood samples were drawn from all the patients after 12 hours of fasting. Fasting Blood Sugar(FBS), Postprandial blood sugar (PPBS) and Lipid profile values were obtained In conclusion, our findings show that elevated serum Total Cholesterol(TC),Low Density Lipoprotein Cholesterol (LDLC), and High Density Lipoprotein Cholesterol(HDLC) levels were associated with an increased risk of hypertension in working age Indian men.. Overall, our results may contribute to the accumulation of evidence that dyslipidemia increases risk of hypertension in Indian population. From a clinical perspective, the importance of strict BP management in patients with dyslipidemia was indicated Among 3554, hypertension patients 86% of them were males and 14% were females. Statistically significant difference was observed in total cholesterol, LDL cholesterol, TC/HDL ratio and LDL/HDL ratio between obese and non obese as well as in CVA, IHD among hypertensive patients relatively with healthy volunteers. Biochemically there was significant difference in total cholesterol, LDL cholesterol, TC/HDL ratio and LDL/HDL ratio between obese and non obese hypertensive patients.

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