World Journal of
Pharmaceutical and Life Sciences

ASSESSMENT ON THE EFFECT OF SELECTED ERGOT-DERIVED DOPAMINE ON THE LIVER FUNCTIONALITY AND INTEGRITY IN WISTAR RATS

*Odinga T., Enebeli S. K., Austin-Asomeji, I., Ohaka, J. C., Gabriel-Brisibe C. U

ABSTRACT

Abuse of drug has become a norm in the society due to people using drugs in doses not prescribed and time. Ergot derived dopamine drugs has been of great advantage in the treatment of ailments and disorders, however, a possible effect on the liver is envisaged, as the liver is saddled with the responsibility of drug metabolism. This study assessed the effect of Bromocriptine and Cabergoline on the liver functionality and integrity. Twenty-five rats grouped into five groups of five rats in each were used for this study. Group 1 was the control group, the rats were administered Low and high dose of Bromocriptine for group 2 and 3, Low dose and high dose Cabergoline for groups 4 and 5. The drugs were administered at the various doses twenty-four hourly. After a period of 21 days, blood samples were collected and Liver harvested for bioassay. On analysis of Albumin, Total protein, Total Bilirubin, Conjugated bilirubin, AST, ALT and ALP using standard laboratory procedures, results revealed that both low and high dose Bromocriptine and Cabergoline increased the serum concentration of total protein, albumin, conjugated bilirubin and total bilirubin, however albumin level showed no significant increase at P value 0.05. The results also observed that the concentration of ALT, AST and ALP all increased when administered High and Low concentrations of Bromocriptine and Cabergoline. The increased variations in AST concentration were significant at P?0.05. The histological examination result revealed that Bromocriptine caused congestion of the central vein, vacuolation and nuclear pyknosis as well as tissue necrosis while those treated with Cabergoline experienced congested central vein, vacuolation nuclear pyknosis and sinusoidal space expansion. The findings of this study therefore suggests that both Cabergoline and Bromocriptine may alter the functionality and integrity of the liver, dose dependent, with the most alteration in Cabergoline.

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