World Journal of
Pharmaceutical and Life Sciences

PHYTO-PHARMACOLOGICAL POTENTIAL OF BUCHANANIA ARBORESCENS (ANACARDIACEAE), ON WOUND HEALING AND CNS DEPRESSENT ACTIVITIES IN ALBINO WISTAR RATS

*Syed Nafeeza, Dr. B. Pushpakumari and Dr. V. Jaya Sankar Reddy

ABSTRACT

To evaluate the wound healing and CNS depressenat activity of methanolic extract of leaves of Buchanania Arborescens (Anacardiaceae) in albino wistar rats. The (MEBA) have been proven experimentally to possess wound healing and CNS depressant activities in invivo methods. Acute toxicity studies of Buchanania arborescens extract can be used safety in the animals up to the dose of 2000 mg/kg body weight. Administration of methanolic extract 200mg (P<0.05) methanalic extract MEBA 400mg (P<0.001) and standard soframycin (P<0.001) significantly inhibited the wound compared to standard group. From this investigation it can be concluded that the MEBA 400mg showed significant healing the wound and comparable to standard sofromycin (P<0.001). Among the extracts the methanolic extract of Buchanania arborescens leaves (MEBA 400 mg/kg) dose showed more prominent depressant activity than the 200 mg/kg dose. The results of the investigations justify the folkoric use of Buchanania arborescens leaves in the treatment of wound and CNS depressant.

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