World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

CHEMICAL FORCE DEGRADATION ASSAY METHOD EVALUATION FOR SIMULTANEOUS ESTIMATION OF MAGALDRATE AND SIMETHICONE IN SUSPENSION DOSAGE FORM

Dr. Osman Ahmed*, Meher Afrin, Ashraf Unnisa, Mohammed Akthar Sulthana and Dr. Anas Rasheed

ABSTRACT

In order to accomplish separation under optimal circumstances following a series of experimental trials, it is necessary to summarise the results. A stationary phase such as the Hypersil BDS C18 (100 mm x 2.1 mm, 1.7 m) column was the most appropriate since it generated symmetrical peaks with high resolution and a very excellent sensitivity, as well as a very good resolution and sensitivity. The flow rate was kept constant at 1.2 mL min-1, indicating acceptable resolution. The reaction of Magaldrate and Simethicone in suspension dose form to the PDA detector was investigated, and it was discovered that the optimal wavelength was 230 nm, which had the maximum sensitivity. Magaldrate and Simethicone were separated using a combination of two solutions, Methanol and chloroform in a 50:50 percent volume ratio, with gradient programming as the mobile phase at 1.2mL/min. This mixture was determined to be an acceptable mobile phase for separation of Magaldrate and Simethicone. The temperature of the column was kept at room temperature.

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