World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Yogeshwari L. Ghule*, Dattaprasad N. Vikhe and Ravindra S. Jadhav


The aim of this review paper is to provide comprehensive summary of in vivo and in vitro Antifertility Models and Antifertility agents. Overpopulation is becoming one of the major global problems causing much influence on the economic, social and natural resources and this intensifies the need of effective birth control measures. This paper also reviews Antifertility activity along with female hormones estrogen and progesterone, which plays important role in hormonal balance in females. In this review paper we have to discusses the various in vivo methods such as sperm motility and count, Vaginal opening, vaginal cornification assay, chick oviduct method, Four- day uterine weight assay, Abortifacient activity, Anti-implantation activity, Antigonadotrophic effect, Mating trial test, Anti- estogenic activity, Anti-ovulatory activity, Progestional activity using mice, rats and rabbits. In vitro methods such as Spermicidal activity, Estrogen receptor binding assay and gestagen receptor binding assay, androgen receptor binding assay.

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