World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ANTI-DIABETIC DRUG CANAGLIFLOZIN AND METFORMIN IN BULK AND DOSAGE FROM

Sunanda Lekurwale*, Siddiqua Shaikh, Sohan Khairnar, Mangesh Lekurwale and Habeeba Shaikh

ABSTRACT

The development and validation of an RP-HPLC technique for the simultaneous Estimation of metformin and canagliflozin in a combined dosage formulation is described in this paper. The mobile phase in this new method is (water 50: Methanol 50 at pH 3) and the column is Cosmosil C18 (250mm x 4.6ID, particle size: 5 micron). Canagliflozin was detected using UV detection at 254 nm, and the drug was eluted after an 8-minute retention time. The method was validated according to the International Conference on Harmonization (ICH) guidelines, with precision, accuracy, linearity, limit of detection, limit of quantitation, and robustness as the parameters. The proposed RP-HPLC approach was found to be useful, practical, and reliable in the routine analysis of metformin and canagliflozin in bulk and dose form.

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