World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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*Pratima Pandey and Pawan Tiwary


Objective: The objective of this study was to synthesize and evaluate the antimicrobial and antihelmintic activity of novel drug derivatives containing indole moieties. Methods: The present work involves the synthesis of indole derivative, where the starting material isatin is refluxed with Hydrazine hydrate in the presence of ethanol at 80° centigrade for 2-4 hours. Maintaining the same temperature samples was evaluated. The reaction was monitored by TLC. After completion of the reaction the product was filtered and recrystallized from hot ethanol, the product 1 was refluxed with chloro acetyl chloride in the presence of ethanol, the product 2 is treated with different anilines. Then anti- microbial studies were done for the synthesized derivatives. The synthesized compounds were evaluated for antihelmintic activity in Pheretima posthuma (earthworm) of nearly equal size (6?1cm). Then the time taken for worms to become motionless was noted as paralysis time & to ascertain death each earthworm was frequently applied with external stimuli which stimulates and induce movements in the worms, if alive.

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