World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FORMULATION AND EVALUATION OF SITAGLIPTIN ORAL DISINTEGRATION TABLETS USING SYNTHETIC SUPER DISINTEGRANTS

M. Mohan Varma, Ashok Thulluru, K. T. Sunil Kumar and Kandivalasa Pavani*

ABSTRACT

The goal of this research is to prepare oral disintegration tablets of Sitagliptin utilising Synthetic Superdisintegrants. By utilising a direct compression approach, oral disintegrating tablets of Sitagliptin were prepared using various ratios of synthetic super disintegrates. The goal of this study was to create and optimise oral disintegrating tablets of Sitagliptin utilising synthetic superdisintegrants to provide a speedy start of action by quickly dissolving in a few seconds without the need for water and to improve patient compliance. In such cases, drug bioavailability is substantially higher and adverse events are significantly lower than in standard tablet dose form. By using IR spectroscopy, drug-excipient compatibility experiments were done, there was no drug-excipient interaction. The 9 formulations of Sitagliptin were prepared varying the concentrations of three super disintegrants: croscarmellose sodium, sodium starch glycollate, and starch 1500. As an immediately compressible vehicle, microcrystalline cellulose was employed. Overall, the results showed that the formulation containing croscarmellose sodium, i.e. CCS3, had a significant advantage over other formulations including the superdisintegrants.

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