World Journal of
Pharmaceutical and Life Sciences

AN OVERVIEW: RESTORING PATHOGENESIS’S ROLE WITH A NEW EMPIRICAL TREATMENT MODULATION IN ULCERATIVE PATIENT

Ladli Kishore*, Arvind Kumar, Shivani Thakur and Ruchika Garg

ABSTRACT

There are few different types of ulcer have different causes such as common ulcer sickness which is erosion in the lining of the stomach or duodenum. Others pressure ulcers is a localized injury range in severity from reddening occurs to the skin to severe, deep craters with exposed muscle or bone which also called bedsores or pressure sores of the skin. The predominant reasons in the Countries are contamination with Helicobacter pylori and use of non-steroidal anti-inflammatory (NSAIDs) drugs; gastric ulcerate is comprehensively acid secretion with average or low while poor mucosal defense in mucus and bicarbonate secretion plays a greater role; multifactorial interactions between mucosal, neuro-humoral factors and the autonomic nervous system plays a pivotal role causes stress ulcer; rises incidence of ulcer due to more consumption of alcohol; genetic factors and other diseases like chronic obstructive pulmonary/airways disease, asymptomatic bowel syndrome, chronic pancreatitis and crohn's disease have pathogenesis associated with ulcer. Hence we explore the possibility classification of the revolutionary treatment of ulcer disease by decrease of gastric acid secretion, H+/K+ ATPase Inhibitor, muscarinic receptor antagonists, mucosal coating agents, etc. and also some herbal medicines and their constituents used in treatment or prevention of ulcer. The aim of present study was to review on various pathogenetic factors, its multifactorial treatment with proper diagnosis, herbal medicines in treating ulcer in world and modulation management of pressure ulcer by occupational therapist through pressure mapping technique under the International Standards Organization (ISO) protocol.

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