World Journal of
Pharmaceutical and Life Sciences

DRAGON FRUIT (HYLOCEREUS COSTARIOENSIS’S) EXTRACT AS ANTIINFLAMATION AND ANTI STRESS OXIDATIVE IN OBESE WISTAR RATS WHICH GIVEN HIGH-FAT DIET

Ni Gusti Made Ayu Dwi Adhi Suastuti and Ni Wayan Bogoriani*

ABSTRACT

A high-fat diet can increase body fat until obesity occurs. Obesity could raise the production of reactive oxygen species(ROS). The production of ROS continuously can caused of oxidative stress which is characterized by increased levels of malondialdehyde (MDA). When oxidative stress occurs continuously it can trigger atherosclerosis and cell damage. The aims of study to determine the potential anti-oxidative and anti-inflammatory activities of dragon fruit extract. Twenty sevens wistar rats which have 150-300 g body weight were separated in 3 groups where each group was given standard feed (control), high fat (HF) and high fat with dosage 100 mg per BW per day of red dragon fruit extract (DFF). Four weeks later blood plasma taken and analyzed contain of MDA, IL-6 and TNF-?.The average values of the parameters show a significant differences were computed by One Way Anova then continued by Post Hoc test. The results of MDA, TNF-? and IL-6 content form blood plasma of wistar rats on a high fat diet showed a significant difference (p<0.05) compared with control rats. Otherwise the decrease of the MDA, TNF-? and IL-6 levels in the rat blood plasma, which fed with dragon’s fruit flesh has a significant difference compared with the high fat group. In his case, it can be concluded that the Dragon fruit extract has potential to prevent the possibility of oxidative stress and inflammation to avoid atherosclerosis.

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