World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

REVIEW ON PHARMACOKINETICS OF VINBLASTINE DRUG AND ITS DELIVERY SYSTEM

Muhammad Abdullah Ikram*, Wajid Iqbal and Hasan Shuja

ABSTRACT

Vinblastine belongs to a class of a drug vinca alkaloids which is a chemical analogue of vincristine. The four major vinca alkaloids that are now used clinically include vinblastine, vincristine, vindesine and vinorelbine. They have been used to treat both Hodgkin and non-Hodgkin lymphomas breast cancer and germ cell tumour. Microtubules are component of cell that provide structural framework that enables cells to divide and grow. Vinblastine act as anti-microtubule agent and produced anticancer affects by causing abnormalities in microtubule formation in cells. This incomplete microtubule formation caused by vinblastine affect the cellular replication and inhibits the process of cell division due to which cell death occur. At the end we will discuss some precision based drug delivery systems which has proved to be very effective in loading drug to its target tissue.

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