World Journal of
Pharmaceutical and Life Sciences

CONSTITUENTS AND ANTIMICROBIAL ACTIVITY OF DICOMA TOMENTOZA GROWN IN SUDAN

Abdel Karim M.*, Amin-Eldin E. and M. Alla

ABSTRACT

Intensive pharmacological reports on the impact of bioactive phytochemicals on human physiology potentiated the applications of medicinal plants. Dicoma is a genus of approximately 35 species in the family Compositeae. Most of these species are small shrubs or even trees and they may grow in diverse habitats including deserts. Dicoma tomentosa is distributed in tropical Africa and Asia.In African system of medicine the plant is used against malaria.In this study, the oil from Dicoma tomentosa seeds has been analyzed by GC-MS. The GC-MS analysis showed 18 components. Major constituents are : 9-octadecenoic acid methyl ester (39.78 % ) ; methyl 5;6-octadecadienoate(24.57%) ; hexdecanoic acid methyl ester(16.57 % ) and 9;12-octadecadienoic acid methyl ester(14.50%) .The antmicrobial activity of the oil has been assessed. At a concentration of 100mg/ml, the oil showed significant activity against Escherichia coli. It also exhibited moderate activity against Staphylococcus aureus, Pseudomonas aeroginosa and Candida albicans.

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