World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

EXPLORING THE COMBINED ANTI-INFLAMMATORY SYNERGISTIC POTENTIALS OF PTEROCARPUS MARSUPIUM STANDARDIZED BARK EXTRACT AND CRATAEVA NURVALA STANDARDIZED BARK EXTRACT

Anupama Yadav*

ABSTRACT

After searching PubMed, Google Scholar, Scopus, and other imperative databases, it was discovered that no combined anti-inflammatory perspectives of Pterocarpus marsupium bark extract and Crataeva nurvala bark extract have been published in an in vitro process (human red blood cells, HRBC). To investigate synergistic behavior, the P. marsupium standardized bark extract (PMSBE) and C. nurvala standardized bark extract (CNSBE) were screened together. PMSBE supported 42.88% membrane stabilization/protection in HRBCs at a concentration of 250 ?g/mL, while CNSBE provided 38.26% membrane stabilization/protection in HRBCs. The anti-inflammatory activity was improved to 59.52% when the extracts PMSBE and CNSBE were measured together (at a concentration of 250 ?g/mL each). When all extracts were used at the same time, the anti-inflammatory value increased from 16% to 21%. Flavonoids, phenols, and alkaloids, which are present in plant products, play a crucial role in mediating anti-inflammatory activity by inhibiting multiple inflammatory enzymes. The extract's strong phenolic and flavonoid content worked together to balance the HRBC membrane in a synergistic way. This study will pave the way for further studies into the discovery of novel herbal formulations for the treatment of acute and chronic inflammation.

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