World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF CASCABELA THEVETIA BARK EXTRACTS FOR HEPATOPROTECTIVE ACTIVITY AGAINST CCL4 AND PARACETAMOL INDUCED HEPATOTOXICITY IN ALBINO RATS

Kamal Jeet* and Shalu Chauhan

ABSTRACT

Cascabela thevetia bark is a poisonous plant native throughout Mexico and in Central America, and cultivated widely as an ornamental. It is a relative of Nerium oleander, giving it a common name yellow oleander, and is also called lucky nut in the West Indies. Therefore evaluated for safety and potential hepatoprotective activity in rodents. The extract (200, 400 mg/kg, p.o) administered to rats and mice over a 24-hour period did not show any signs of toxicity or mortality, suggesting that the oral LD50 of the hydroalcholic extract (in rats and mice) was beyond 400 mg/kg. Daily administration (200, 400 mg/kg; p.o) of extract for 9 days did not cause any changes in behavior or alterations in hematological parameters of the animalsthe results indicate that the hydroalcholic extract of Cascabela thevetia bark is toxic and may exhibit hepatoprotective activity at lower doses by enhancing antioxidant protection in the cell bioactivation of hepatotoxic agents.

[Full Text Article]   [Download Certificate]