World Journal of
Pharmaceutical and Life Sciences

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF CARICA PAPYA GROWN IN SUDAN

Abdel Karim M.*, Amin-Eldin E. and M. Alla

ABSTRACT

Carica papya is a large perennial plant in the family Caricaceae. This plant is cultivated in tropical and subtropical regions for its economic and medicinal importance. All parts of the plant are used as natural remedy against a wide array of ailments.In this study, the oil from Carica papya seeds has been analyzed by GC-MS. The GC-MS analysis showed 20 components. Major constituents are : i) 9-octadecenoic acid methyl ester (28.06 % ) ii)oleic acid (12.86%) iii) ethyl oleate(11.52 %) iv)hexadecanoic acid methyl ester(7.78%) v)stigmasterol (7.57%) vi)2-dodecen-1-yl(-) succenic acid anhydride (5.85%) and vii)gamma-sitosterol(5.40%). The antmicrobial activity of the oil has been assessed. At a concentration of 100mg/ml, The oil showed significant activity against Escherichia coli and Pseudomonas aeroginosa .It also exhibited moderate activity against Bacillus subtilis and Staphylococcus aureus beside weak anticandidal activity.

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