World Journal of
Pharmaceutical and Life Sciences

SYNTHESIS AND CHARACTERIZE NEW HETEROCYCLIC COMPOUNDS DERIVATIVES FROM DIAZONIUM SALT DERIVATIVES

*Hiba H. Ibraheem, Nisreen Kais Abood and Ali Jabbar Salim.

ABSTRACT

Diazonium salts[1,2] were synthesized by the reaction of salicyldehyde with different primary amine. And then refluxed compounds[1,2] with appropriate amine to form Schiff Bases derivatives.[3-6] New derivatives of ?-lactam[7-10] were synthesized by the reaction of Schiff Bases derivatives[3-6] with chloroacetyl chloride in presence triethylamine. Then cyclization of compounds[3-6] with mercapto acetic acid in presence dry benzene to give thiazolidenones derivatives.[11-14] All synthesized compounds were characterized by measurement melting point, FT-IR spectral, Elemental Analysis and some of them by 1H-NMR spectral.

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