World Journal of
Pharmaceutical and Life Sciences

FORMULATION AND PHYSICAL STABILITY STUDY OF NANOEMULSION GEL (NANOEMULGEL) CONTAINING BELIMBING WULUH (AVERRHOA BILIMBI L.) ETHANOLIC EXTRACT

Made Laksmi Dewi Dhyaksa and Mahdi Jufri*

ABSTRACT

Objective: Belimbing wuluh (Averrhoa bilimbi L.) is one of the plants that is potentially used as a source of antioxidants. Natural antioxidant contents such as vitamin C, carotenoids, flavonoids, tannins, and other polyphenol compounds are believed to prevent the photoaging process. The aim of this study is to formulate the ethanolic extract of Belimbing wuluh (Averrhoa bilimbi L.) into nanoemulsion gel dosage form and test its physical stability and antioxidant activity. Methods: Nanoemulgel was prepared by high pressure homogenizer method in various extract concentrations i.e. 1%, 2%, and 3%. The formulated nanoemulsion gel then tested for their physical stability using several methods, i.e. long-term stability tests, and cycling test.. In addition, an antioxidant capacity study was also carried out by using DPPH (2,2,-diphenyl-1-picryl hydrazil) damping method. Results: Nanoemulgel showed a stable physical appearance for 12 weeks at room temperature (25 ± 2oC), high temperature (40 ± 2oC), cycling test, and mechanical test. However, on a long-term physical stability test in low temperature (4 ± 2°C), all nanoemulgel undergone the Ostwald Ripening phenomena. The results of in-vitro antioxidant activity study showed poor IC50 value, i.e. 20520.09 ?g/mL (F0); 18392.29 ?g/mL (F1); 17868.80 ?g/mL (F2); and 17287.625 ?g/mL (F3), respectively. Conclusion: The formula is not an optimal formula to produce a nanoemulgel with good physical stability and antioxidant activity.

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