World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, Scholar Article Journal Index (SAJI), International Scientific Indexing ( ISI ), Scope Database, 



M. Madhu Babu*, P. Krupa Rani, Ch. Sharika and D. Manasa Devi


Sepsis is a complex condition characterised by the simultaneous activation of inflammation and coagulation in response to microbial entry. These events manifest as systemic inflammatory response syndrome or sepsis symptoms through the release of pro inflammatory cytokines, pro coagulants, and adhesion molecules from immune cells and damage endothelium. Today, sepsis is a severe multisystem disease with difficult treatments and high mortality rate. So, the drug cilengitide has developed to treat sepsis and to decrease the mortality rate because, all antibiotics that used in sepsis which involve in inhibiting the bacterial growth but they does not stop bacterial attachment to endothelial cells this cause bacteria to spread / reach to major organs (vital organs) i.e. accumulation of fluids in major organs may takes place and cause septic shock/ organ failure. Here, this review summarizes that cilengitide is an antagonist of the major endothelial cell integrin, alpha-v beta-3 & this integrin is an adhesion molecule that mediates the adhesion of cells to the extracellular matrix and work effectively in stabilizing the blood vessels so that they cannot leak bacteria and infect major organs.

[Full Text Article]


World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here