World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, Scholar Article Journal Index (SAJI), International Scientific Indexing ( ISI ), 



Ihimire I. G.*, Alaiya H. T. and Onobun D. O.


This study investigated the effect of administration of acute and sub-lethal dose of Azadirachta indica in animal model. Eighteen (18) mature Wistar albino rats were used to investigate lethal dose LD50 and establish safe dose (SD) in 24 hours. Another 18, divided into 6 Groups A – E were used to investigate the biochemical effect of administration of different doses of the extract. Group A served as control and received only water daily. Group B received 1 mL of extract 547.72 mg/kg body weight being the safe dose established. Group C – F respectively were given 492.95 mg, 602.49 mg, 657.26 mg or 711.89 mg/kg body weight in 1 mL for 14 days. Water and feed were provided ad libitum. On the 15th day, the animals were humanely sacrificed, blood collected by cardiac puncture and some organs/tissues were excised. Standard methods were used to assess in triplicate Some biochemical parameters. Mean values of these analytes were calculated and compared with Turkey-Kramer multiple comparison test. Results were presented as mean ± standard error of mean. Administration of the dose recorded comparable final weight as control, 184.87 ± 1.97 g and also liver, heart, spleen and kidney weight too. Group administered the safe dose i.e. Group B recorded evidence of liver protection effect with lower AST value compared to control. This study provided rational biochemical evidences for adequate usage of the extract.

[Full Text Article]


World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here