World Journal of
Pharmaceutical and Life Sciences

STUDY OF PREVALENCE AND PREVALENT PHENOTYPIC CHARACTERISTICS OF INFERTILE WOMEN WITH PCOS ATTENDING DEPARTMENT OF OBSTETRICS AND GYNECOLOGY / MOSUL GENERAL HOSPITAL IN IRAQ

Maha Saleem Mohammed Ali*

ABSTRACT

Polycystic ovary syndrome (PCOS) is a major cause of annovulatory infertility worldwide. It is important to determine the prevalence and characteristic features of PCOS in different environments. This study aimed to determine the prevalence and the prevalent phenotypic characteristics of infertile patients with PCOS. This cross-sectional study was conducted on (87) women who attended the Department of Obstetrics and Gynecology / Mosul General hospital in Iraq between January and June 2019. Data collected from each patient included age, parity, height, weight, degree of hirsutism (using modified Ferriman-Gallway scoring), antral follicle count and ovarian volume. Other parameters included estimation of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, progesterone and testosterone for each patient. Results showed that Polycystic ovarian syndrome (using Rotterdam criteria) occurred in 20.7% (18) of infertile patients. Hirsutism occurred in 61.1% (11) of infertile women with PCOS but in 13.3% (8) of infertile women with normal ovaries (P=0.005). Oligomenorrhoea occurred in 27.7% (5) of infertile women with PCOS and in 3.3% (2) of infertile women with normal ovaries (P=0.03). Significantly more infertile women PCOS had anovulation as the mean mid-luteal progesterone (5.21±3.91ng/ml) was less than that for women with normal ovaries (18.12±9.9 ng/ml) P=0.005 and higher mean testosterone level was also observed in infertile women with PCOS (0.99±0.18IU/L) than in those with normal ovaries (0.41±0.14IU/L) P < 0.005. It can be concluded from this study that the prevalence of PCOS in women with infertility was 20.7%. The infertile patients with PCOS had statistically higher occurrence of annovulatory cycle with oligomenorrhoea, hirsutism and serum testosterone levels compared to infertile women with normal ovaries.

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