World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

CLINICAL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF VIDANGADI YOGA (AYURVEDIC POLYHERBAL MEDICINE) IN TYPE 2 DIABETES MELLITUS

Dr. Twinkle Gupta and Dr. Vibuti Sharma*

ABSTRACT

Background and objectives: Prevalence of diabetes mellitus (DM) is rapidly rising throughout the globe at an alarming rate, where India leads with largest number of diabetics and became “diabetes capital of the world.” Incidence of diabetes mellitus is increasing due to genetic predisposition, high body fat, and insulin resistance. Though multiple oral hypoglycaemic agents and insulin are available, these are associated with side effects, primary and secondary failure. Hence, evaluation of antidiabetic potential of medicines described in traditional health sciences such as Ayurveda (Indian system of medicine) is also important. This study aimed to assess the efficacy and safety of Vidangadi Yoga (ayurvedic polyherbal medicine) in the management of type 2 diabetes mellitus (T2DM). Methods: Total 31 patients were taken for this clinical research. They are divided into two groups, group A and B, given Vidangadi Yoga 4 g & 2 g TDS respectively for three-month follow up. They are investigated against their blood glucose, HbA1C and liver profile tests. Patients were also investigated for subjective parameters viz polyurea, polyphagia, exhaustion and constipation and their response has also been noted regarding palatability acceptance and ease of administration. Results: Patients has responded positively for formulation. Decrease in FBS and PPBS were found highly significant (P ? 0.001) in both groups but more in higher dose (group A). Decrease in HbA1C is also found highly significant in both groups. In LFT, SGOT level were also decreased more in group B in comparison to group A, and it is significant (P = 0.017 and 0.002). SGPT level were also decreased more in group B in comparison to group A, and it is significant in group B (P= 0.085 and 0.002). Conclusions: Vidangadi Yoga was found significant not only in controlling blood sugar but also in management of other factors related to diabetes mellitus.

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