World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

STUDY OF EMPIRICAL THERAPY WITH COMBINED CIPROFLOXACIN EFFICACY VERSUS TOPICAL DROPS ALONE IN TUBOTYMPANIC CHRONIC SUPPURATIVE OTITIS MEDIA

*Abdul Wahhab Mohsin Ahmed

ABSTRACT

One of the prevailing otologic infections is chronic suppurative otitis media, especially the tubotympanic type for which various treatment protocols are followed. Usually, oral and topical antibiotics (mainly quinolones) are given alone or in combination. There is a lack of consensus as to whether topical drops alone are effective or a combined oral and systemic therapy should be prescribed. In our study, we have attempted to observe the efficacy of empirical therapy with combined ciprofloxacin versus topical drops only in patients with tubotympanic chronic suppurative otitis media for control of infection. In this study, a total of (150) patients visiting the outpatient ENT department at our Haditha general hospital/Iraq with clinically diagnosed chronic suppurative otitis media (tubotympanic type) were enrolled in our study. A detailed proforma was filled for all patients. All patients after aural toilet were subjected randomly to one of the 2 treatment methods, ie, topical ciprofloxacin ear drops plus an oral placebo or combined oral and topical ciprofloxacin, and the patients were reviewed after 1 week of treatment. It was observed that 71 of 75 (94.7%) patients responded to treatment in the group receiving topical ciprofloxacin, whereas 71 of 75 (98.7%) patients responded in the group receiving combined therapy. This difference was not significant. Moreover, age, sex and duration of discharge did not have any effect on treatment. There were minimal side effects in both groups, which were also not significant and disappeared after discontinuation of treatment. It can be concluded from this study that topical ciprofloxacin drops were as effective as combined oral and topical ciprofloxacin and that the addition of oral drug did not have any beneficial effect and added only to the cost of treatment.

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