Abstract
DEVELOPMENT AND OPTIMIZATION OF ERLOTINIB HYDROCHLORIDE ANALYTICAL METHOD BY USING QUALITY BY DESIGN APPROACH
Bandana Kumari*
ABSTRACT
A reversed-phase high performance liquid chromatographic (HPLC) technique for the determination of Erlotinib Hydrochloride has been optimized using analytical quality by design (QbD) approach. All the compounds are monitored with the photodiode array (PDA) detector at 336 nm. The experiments were conducted by changing the three different factor, that are pH, concentration of methanol and flow rate by using of a 23 factorial design space. The whole technique is developed as per International Council for Harmonization (ICH) guidelines. The proposed method is robust, sensitive, rapid and successful and helpful in the regions where regulatory agencies recommend HPLC analytical method.
[Full Text Article] [Download Certificate]WJPLS CITATION
All | Since 2019 | |
Citation | 422 | 322 |
h-index | 9 | 7 |
i10-index | 4 | 2 |
INDEXING
NEWS & UPDATION
BEST PAPER AWARDS
World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .
Best Article of current issue
Download Article : Click here