World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF ISOSORBIDE DINITRATE

Somya Sah*, Ashutosh Badola, Preeti Kothiyal

ABSTRACT

The aim of the present research was to formulate and evaluate sublingual tablets of Isosorbide Dinitrate, belonging to the class of anti-angina drug. The tablets were prepared by direct compression technique. The surfactants in the formulation include the Croscarmellose Sodium, Sodium starch glycolate, crospovidone in different ratios. The polymer used in the formulation includes the poloxamer that act as a surfactant and also the wetting agent that causes the rapid and effective disintegration of the tablet and the other excipients. The formulation (F5) was found to disperse at the least time of 5+.02 seconds and the total time for disintegration was found to be 3 + .14 minutes. The drug content was found to be 99.19%. The tablets were showing hardness of 3+.5. The tablets was found to show the friability of .52+.03 %. In-vitro study profile of the formulation proves that all the formulations showed the optimal release within specific time duration. The release kinetic study revealed that formulationF5 showed non fickian release mechanism and show zero order kinetic. According to the evaluations done on the various formulations it was observed that the formulation number 5 (F5) showed the best result as the disintegration time required was less as compared to other formulations.

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