World Journal of
Pharmaceutical and Life Sciences

ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC ACTIVITY OF MURRAYA KOENIGII BARK EXTRACT

*Rama Chandra Rout, Prof. (Dr.) Prasanna Kumar Panda and Dr. Gurudutta Pattanaik

ABSTRACT

In this research work albino male rats were randomly divided into four groups I.e. G-1,Gr-2, Gr-3 and Gr-4.Gr-1 and Gr-2 were served as vehicle control groups(Demineralised water) and Triton control (Triton WR-1339,200mg/kg IP).Gr-3 and Gr-4 were served with Atorvastatin(7.2 mg/kg) test sample 400 mg/kg/day as single dose for two days respectively. In the second study albino rats were divided into five groups, out of five groups 1st and 2nd groups were normal and diabetic control group respectively.Gr-3,Gr4,Gr-5 which are called as diabetic group were treated orally with Murraya Koengii bark extract (200mg/kg b.w,400 mg/kg b.w.,800 mg/kg b.w.) for 28 days. Sixth group was treated with Gliclazide(25mg/kg b.w). In the OGTT, it is found that the extract OD, extract BD and glyclazide treated group glucose level decreases non significantly at 60 mins and 120 minutes. It indicates that Murraya Koengii bark extract showed supportive action and also with STZ and NA induced rats significantly blood, glucose and also able to lowers the lipid by the same extract.

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