World Journal of
Pharmaceutical and Life Sciences

ALZHEIMER’S DISEASE (AD) INDUCED TOXICITY ON BRAIN TISSUE TOTAL ATPASE, Mg2+AND Ca2+ATPASES IN WISTAR STRAIN MALE ALBINO RAT WITH CONCERNING OF RED GRAPE SEED EXTRACT (RGSE)

S. Allabakash, V. Uday Kiran, Dr. K. Peera and *Prof. K. Yellamma

ABSTRACT

D-Galactose toxicity can upset brain chemistry leading to depression, nervousness, and destabilized immunity. In people with Alzheimer’s disease (AD), the increasing devastation of learning and memory eventually leads to a definitive diagnosis. The chief principle of the present study was to estimate the ameliorative effect of Red Grape Seed Extract (RGSE) on the brain of 24 male albino rats after introduction to D-Galactose toxicity. In the present study Age matched rats were be divided into 4 groups of six in each group and treated as follows: Group-I. Control (CN) rats received 0.9% saline(1ml/kg body weight).Group-II. Rats treated with intraperitoneally (IP) administered with D-Gal (120 mg/kg body weight) up to end of the experiment. Group-III. Rats injected with saline for first six weeks and from 7th week onwards treated with Red Grape Seed Extract (RGSE) ethanol extract (100mg/kg body weight) orally for 60 days. Group-IV. Rats injected with D-Galactose intraperitoneally (120 mg/kg body weight) for six weeks, and then followed by simultaneous oral administration of Red Grape Seed ethanol extract (100mg/kg body weight) for another 60 days. The animals were sacrificed by cervical dislocation. Mean while isolated the Brain tissue and calculated the activity levels of Total ATPase, Mg2+ and Ca2+, while the treatment with RGSE affected the alterations in these parameters. AD induced experimental rats treated with Red Grape Seed Extract (RGSE) recorded a phenomenal elevation in Total ATPases, Mg2+ and Ca2+, ATP ases. Meanwhile the combination treatment (RGSE+D-Gal) reveals that significant elevation of Total ATPases, Mg2+ and Ca2+, ATPases was seen in experimental groups. Evidently, this review reveals that RGSE play a key role to enhance all energy metabolisms in AD induced rats and increase the neurotransmitters in brain system.

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