World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

IMPROVED ANTIFUNGAL ACTIVITY OF CLOTRIMAZOLE EMULGEL AGAINST CANDIDA ALBICANS

Sandeep Gupta, Priyanka Chaturvedi, Abhishek Banke, Surendra Kumar Jain and Durga Pandey*

ABSTRACT

Aim and objective of the study is to prepare and evaluate emulgels of Clotrimazole. Formulations were prepared by using Carbomer, Liquid Paraffin, Span 20 Tween 80, Propylene Glycol and Water. Developed formulations of Clotrimazole were evaluated for the physiochemical properties such as Spreadability 14.89 gcm/sec, Viscosity 3985 cP, pH 7.02, for optimized formulation, texture was found smooth and white cream. Melting point of emulgel was 147-149 C. Mean particle size of nanoemulsion was found 101.1 nm and SEM shows 200 nm droplet size, Cumulative percentage drug release was 98.98 in 6 hours from optimized formulation. Antifungal activity of emulgel against Candida albicans was more than marketed gel of same drug.

[Full Text Article]

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