World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

DESIGN AND EVALUATION OF CONTROLLED POROSITY OSMOTIC PUMP TABLET OF NIFEDIPINE FOR BUCCAL DELIVERY

R. Kumaravelrajan1*, L. Abungsana Singh1, Priyanka Mitra1 and V. Suba

ABSTRACT

The objective of the present study is to develop, optimise and evaluate of Buccal Osmotic Pump Tablet (BOPT) of Nifedipine. Nifedipine was choosen as drug candidate to carry out the objective of the study. The DSC thermograms were clearly proved that there was no specific interaction between the drug and polymer used in the formulation. Lactose and lactose-dextrose combined was used as osmogent. Different drug: osmogent ratios are used to investigate the study. The release of drug from the osmotic pump is dependent on Osmotic pressure inside the system. The percentage of pore former concentration was directly proportional to the drug release. 30% pore forming agent concentration, drug release rate is only at the end of 8 hr however, release rate was increased as increased the % of pore former concentration, 40% showed 74.8% and 50% (F3) showed 83.2%. The formulations with 4% coating thickness showed greater amount of release rate when compared with other formulations with 7% and 10% coating thickness. Thickness of the membrane is inversely proportional to the drug release. The optimised batch (F9) showed good ex vivo permeation of the drug, around 80% of the drug permeated at the end of 6th hour, muco adhesive strength and wash off test results showed good adhesive property on buccal membrane. SEM study showed the porosity of the membrane in situ condition of the Nifedipine BOPT, before contact to aqueous environment there was no pores on the membrane but after contact pores were formed was observed.

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