World Journal of
Pharmaceutical and Life Sciences

HISTORICAL ASPECTS OF DIABETES AND DIABETIC NEUROPATHY

Zaffar Hussain* and Mohd Afsahul Kalam

ABSTRACT

Diabetes mellitus and its complications relating to nerves has not been mentioned in ancient times except by Ibn Sina (980-1037AD), also known as Avicenna, an Arab philosopher, who proposed possible familiarity with diabetic disorders in his famous book „Canon of medicine? in which he mentioned two specific complications of diabetes mellitus namely gangrene and collapse of sexual function. It was not till the 18th century that Western physicians started studying and examining diabetes mellitus and its related complications. Ultimately, the works of the 19th century (de Calvi, Pavy) clearly recognized the relationship between diabetes mellitus and diabetic neuropathies. The important discovery of insulin in 1921 by Frederick G Banting, Charles Best and John Macleod crank up a wide interest and more systematic approach to research of diabetic complications, leading to S. Fagerberger?s conclusion that numerous of them share the fundamental micro vascular pathology.

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