World Journal of
Pharmaceutical and Life Sciences

AMELIORATING EFFECT OF CURCUMA LONGA ON FENVALERATE INDUCED TOXICITY IN BIMODAL OXYGEN UPTAKE OF A FRESHWATER AIR BREATHING FISH CLARIAS BATRACHUS

Pratibha Kumari and Dilip Kumar Paul*

ABSTRACT

The present paper deals with the ameliorating effect of aqueous extract of a medicinal plant Curcuma longa (turmeric) on a pyrethroid pesticide fenvalerate induced toxicity in bimodal oxygen uptake of a freshwater air-breathing fish Clarias batrachus (Linn) popularly known as mangur. The fishes after proper acclimatization and giving adequate food, fishes were intoxicated with fenvalerate at the doses of 1/3rd, 1/6th, 1/9th and 1/10th of LC50 (i.e. 0.247 ppm) for 96 hours. Control group of fishes showed oxygen consumption level to 68.823± 1.947 ml/kg/hr if surface was allowed while it was more i.e. 71.083±5.144 ml/kg/hr when surface was prevented. Decreasing trend of oxygen uptake in the fishes was found in both the cases after intoxication of the fenvalerate. The trend was due to the stress conditions of fishes correlated with low values of RBC and hemoglobin level as a result of pesticide inhalation. Curcumin, the main constituent of Curcuma longa was found to ameliorate the effect of pesticide on oxygen uptake rate of the fishes making almost its normal level of oxygen uptake rate of the control fishes.

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