World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ACUTE ORAL TOXICITY AND ANTI TUSSIVE EFFECT OF KOFASIL SYRUP (POLY HERBAL FORMULATION) ON SO2 INDUCED COUGH MODEL

Nilesh Patel, Dr. Janmejay Patel, Achal Patel and Prof. Dr. Upendra U. Zala*

ABSTRACT

Introduction- The herbal drugs mentioned in classics for treatment of airway infections are better than modern drugs like anti-tussive, expectorants, mucolytics etc., as they have no any side effect. Aim: To evaluate acute oral toxicity on swiss albino mice and anti tussive effect in So2 induced cough model of kofasil Syrup (Anti-tussive poly-herbal formulation). Method: The present study was conducted according to OECD guideline AOT-425 to know single dose toxicity of Kofasil Syrup on swiss albino mice. IAEC No. for the study is SKPCPER/IAEC/2016-02/02. Each mouse was treated with a single oral dose of 2000 mg/kg of extract in sequence at 48 h intervals. Body weight of all animals was recorded once in a week. The anti tussive effect was evaluated in SO2 induced cough model in mice by method as describe by Miyagoshi et al., 1986 with modified and simplified. Results: Body weight of all animals did not reveal any significant change as compared to vehicle control group. Mortality was not observed in any animal of a group. Kofasil Syrup showed significant decrease in cough bouts in compression to standard treated (Codeine Sulphate) group. Conclusion: The study shows that Kofasil Syrup (Anti -tussive poly-herbal formulation) did not produce any toxic effect at dose of 2000 mg/kg. So No-Observed-Adverse-Effect-Level (NOAEL) of Kofasil Syrup is 2000 mg/kg. The significant decrease in cough bouts proves potential anti tussive activity of Kofasil Syrup.

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