World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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P. Sreenivasa Prasanna, K. Thejomoorthy, A. Naganjaneyulu and Bhukya Vagya*


The main aim of proposed work was to develop Rivaroxaban matrix tablets, sustained release dosage form. Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The sustained release tablets were prepared by direct compression method using Hydroxylpropylmethyl cellulose (HPMC K4M,K15M), and Guar gum in varying ratios. Tablets blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability, and drug content. The granules exhibited satisfactory rheological demeanor. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 12 hours using paddle method in phosphate buffer (pH 6.8) as dissolution media. Among all the formulations, F6 formulation shows maximum drug release at the end of 12hrs and it follows first order with non fickian diffusion.

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