World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF RIVAROXABAN SUSTAIN RELEASE MATRIX TABLETS

P. Sreenivasa Prasanna, K. Thejomoorthy, A. Naganjaneyulu and Bhukya Vagya*

ABSTRACT

The main aim of proposed work was to develop Rivaroxaban matrix tablets, sustained release dosage form. Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The sustained release tablets were prepared by direct compression method using Hydroxylpropylmethyl cellulose (HPMC K4M,K15M), and Guar gum in varying ratios. Tablets blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability, and drug content. The granules exhibited satisfactory rheological demeanor. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 12 hours using paddle method in phosphate buffer (pH 6.8) as dissolution media. Among all the formulations, F6 formulation shows maximum drug release at the end of 12hrs and it follows first order with non fickian diffusion.

[Full Text Article]

BEST PAPER AWARDS

World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here