World Journal of
Pharmaceutical and Life Sciences

RELATIONSHIP BETWEEN HYPERURICEMIA AND PERINATAL OUTCOMES AMONG PREGNANT HYPERTENSIVE WOMEN

*Dr. Mehasin Kamal Saleh Zuwayd and Dr. Faeza Kamal Salih

ABSTRACT

This study aimed to determine the relationship between hyperuricemia and perinatal outcome in pregnancy induced hypertension. This prospective and observational study was carried out in Al-Falluja Teaching Hospital for Gynecology and Pediatrics – Falluja-Anbar /Iraq. The study included (75) primigravida female patients in the third trimester (after 32 weeks gestation) with pregnancy induced hypertension. Serum uric acid assay was done then the patients were classified into three groups according to uric acid levels; Group I (low hyperuricemia) uric acid below 25th percentile (<3.7 mg/dl ), group II (middle hyperuricemia) uric acid from 25th to 75th percentile (3.8 to 5.7 mg/dl ) and group III (high hyperuricemia) uric acid above 75th percentile (>5.8 mg/dl). The maternal outcome was followed up as (eclampsia, HELLP, acute renal failure and accidental hemorrhage) and fetal out- comes (stillbirth, prematurity, IUGR and IUFD). The results showed statistically significant increase of serum uric acid, urea and creatinine in high group compared to middle and low ones. Bad fetal outcome and pregnancy complications were directly proportional to the serum uric acid levels. It can be concluded for our study that hyperuricemia may be used in the prognosis of adverse perinatal outcomes in pregnancy induced hypertension, and that serum uric acid levels is a useful and inexpensive marker for predicting adverse perinatal outcomes.

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