World Journal of
Pharmaceutical and Life Sciences

TRANSUNGUAL: THE NOVEL DRUG DELIVERY SYSTEM

Pratik V. Malvade*, Sayli R. Chavan, Dhanashri B. Bhagat, Komal R. Ghorpade

ABSTRACT

The tranungual drug delivery system or nail drug delivery system is very effective on nail disorders. The transungual drug delivery is directly interact with infected part of nail and it cure infected part very rapidly as compared to oral route drugs or other any route of administration of drugs. And this drug delivery system is with minimum adverse effects on body. But after too many good things the some difficulties are also present in this system i.e. the permeability of nail is quite low which affects permeability of drug across the nail. Hence in this review article we discussed about anatomy of nail, some disorders of nail and penetration enhancing methods. The drug delivery through nail plate are used in nail plate e.g. onychomycosis, green nail syndrome, paronychia and leukonychia. The nail disorders are mainly cause due to fungal or any microbial infection. The some formulations which are generally prescribed are Ciprofloxacin, Levofloxacin, Itraconazole, and Fluconazole. The some factors also affects the penetration power of nail are molecular size of drug, concentration of nail and vehicle used in formulation. In this review article we collect the information about nail anatomy, disorders of nail, drug penetration enhancing methods and treatment on the nail disorders.

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