World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

AN IN VITRO STUDIES ON EMERGENCE OF RESISTANCE IN FLOROQUINOLONES IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN POULTRY

Sandip Vishnu Ther, Meena Ther and Satish Shukla*

ABSTRACT

An attempt to induce resistance to enrofloxacin in vitro was made against isolates of Pseudomonas aeruginosa isolated from poultry birds. This artificial exploitation of strains resulted in the increase of minimum inhibitory concentration from 0.3?g/ml to 1 ?g/ml of original strain to 8.0 to 11.5 ?g/ml indicating development of resistance to enrofloxacin (Ex) and a major decrease in size of zone of inhibition of ciprofloxacin (Cf) and levofloxacin (Le) indicating cross resistance to these agents. Results indicate the induced resistance to enrofloxacin can promote development of cross resistance to other flouroquinolones. This indicates that of alertness is required whiles using flouroquinolones for the treatment of pseudomonas aeruginosa infections in poultry.

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