World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ESTIMATION OF ANNONA SQUAMOSA FOR ANTI-DEPRESSANT ACTIVITY

Dr. Juluri Krishna Dutta Tejaswi*

ABSTRACT

The anti-depressant activity of Ethanolic root extract of Annona Squamosa (EREAS) belongs to the family Annonaceae by oral administration at dose according to the body weight in a sequential manner in healthy albino rats was done by using Imipramine as standard drug. Forced swim test (FST) and Tail suspension tests (TST) was done on plant extract given in three doses (100, 200 and 300mg/kg) by dose dependent manner. 300mg/kg plant extract showed decreased immobility time near as to that of the standard drug. The decrease in immobility period in both the models was observed starting from 200 mg/kg. But the increase in dose from 200 to 300 mg/kg produces further reduction in immobility period.

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