World Journal of
Pharmaceutical and Life Sciences

NOVEL APPROACHES FOR SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS

Roobal Chaudhary* and Gagandeep Kaur

ABSTRACT

Solubility is one of the most critical criteria for achieving optimal concentration of the drug in systemic circulation to exert therapeutic effect. Solubility can be defined as the solute dissolving phenomenon to give a homogenous system. An effective formulation depends on how effectively drug is made available at the place of action. Drugs having high aqueous solubility get absorbed through GIT membrane and reaches in systemic circulation easily. Poor aqueous solubility is the main problem facing the development of new API formulations and generic production. The solubility and dissolution rate of poorly soluble drugs must therefore be increased, because these drugs are weak in absorption and less bioavailable. This review is intended to with discuss thoroughly different techniques employed to enhance the aqueous solubility along appropriate examples of drugs whose solubility is enhanced by these techniques. There are number of solubility enhancement techniques include micronization, nanonization, super critical fluid method, spray freezing into liquids, hydrotropy method, solid dispersion, salt formation, co-solvency, addition of solubilizing agents, complexation and pH adjustment etc. Selection of the method for enhancing the solubility depends on the drug properties, the site of absorption and the features of the appropriate dosage type. The purpose of this review article is to describe BCS classification system, various solubility enhancement techniques of poorly soluble drugs with increased bioavailability for successful absorption and also tried to focus on the factors affecting process of solubilization.

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