World Journal of
Pharmaceutical and Life Sciences

DESIGN AND EVALUATION OF FLUCONAZOLE LOADED ANTIDANDRUFF HAIR GEL

N. G. Raghavendra Rao, Yogita Tyagi and Manisha Uniyal*

ABSTRACT

Dandruff is a common clinical condition caused by increased growth of fungi and bacteria, it is a flaking of dead skin and over activity of the oil glands, known as seborrhea. Dandruff is a shedding of dead skin cell from the scalp and is suffered by almost 50% of the population and couses significant discomfort. Fluconazole is a imidazole derivative. It is used for the treatment of local and systemic fungal infection. Increased growth of fungi and bacteria on the scalp couse dandruff and seborrheic dermatitis which results in abnormal proliferation, scaling and flaking of scalp epidermis. Dandruff is commonly treated using shampoos or lotions cantaining imidazole, selenium sulphide, salicylic acid and zinc pyrithion. Shampoos or lotions do not use the long duration on the scalp and these cannot prevent reoccurrence. Hair gel last long on the scalp. In persent study was degined to formulate and evaluate different formulae of antidandruff gel containing fluconazole for treatment of dandruff. The fluconazole antidandruff hair gel was formulated by using different polymars with different concentration as carbopol 940, polyethyleneglycol, methyl peraben, glycerine, triethanolamine, polyvinyl pyrrolidone.

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