World Journal of
Pharmaceutical and Life Sciences

CONSTITUENTS AND ANTIMICROBIAL ACTIVITY OF SUDANESE FOENICULUM VULGARE MILL. (APIACEAE.) OIL

Abdel Karim M.*, Magid A. and M. Alla

ABSTRACT

In developing countries, ethnomedicine is still playing a vital role in primary health care and intensive pharmacological reports on the impact of bioactive phytochemicals on human physiology potentiated the applications of medicinal plants. Fennel (Foeniculum vulgare Mill.) is a perennial herb in the family Apiaceae. The plant is widely used as a flavouring agent in foods. Fennel seeds are hypotensive and diuretic. In this study, the oil from Foeniculum vulgare seeds has been analyzed by GC-MS. The GC-MS analysis showed 58 components. Major constituents are : 9- octadecenoic acid (Z)-, methyl ester(35.59%):9, 12-octadecadienoic acid (Z, Z)-, methyl ester (29.36%),and hexadecanoic acid, methyl ester (8.02%). The antmicrobial activity of the essential oil has been assessed. At a concentration of 100mg/ml, the oil showed significant anticandidal activity. It also exhibited good activity against Gram positive Staphylococcus aureus, Bacillus subtilis and Gram negative Escherichia coli. However it failed to give inhibitory effect against Gram negative Pseudomonas aeruginosa.

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