World Journal of
Pharmaceutical and Life Sciences

PREVENTIVE THERAPIES USING SODIUM CHANNEL BLOCKERS FOR CONGENITAL LONG QT SYNDROME

Dr. Toshimasa Nakada*

ABSTRACT

Preventive therapy for pediatric patients with congenital long QT syndrome (LQTS) without severe cardiac symptoms has not been established. The objective of this study was to clarify the outcomes of pediatric patients with LQTS who were diagnosed without severe cardiac symptoms and who received preventive therapy using sodium channel blockers (SB). This retrospective study included data from seven patients with LQTS who received preventive therapy using SB. The outcomes of those patients and changes of corrected QT intervals (QTc) before and after treatment were studied. Three patients received mexiletine alone, and four patients received combination therapy with propranolol and SB. The median follow-up period from the initial treatment to the last follow-up was one year and one month (range: 6 months to 15 years and 6 months). No cardiac events developed after treatment. The QTc values after therapy were significantly shorter than those before: median QTc 454 (range: 396–475) vs. 485 (range: 470–527) ms, P < 0.05.

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