World Journal of
Pharmaceutical and Life Sciences

COMPARATIVE ANTIMICROBIAL STUDY OF A LOCALLY PRODUCED DISINFECTANT AND SOME COMMERCIALLY AVAILABLE DISINFECTANTS AGAINST SOME CLINICAL ISOLATES

Oleghe P. O.*, Agholor K., Lucy F. O., Racheal S. and Oboh J. E.

ABSTRACT

The main goal of the present study was to determine the efficacy of five routinely used disinfectants and a locally produced one against some selected clinical isolates. The disinfectants used in this study were Roberts® antiseptic disinfectant, Tetmosol® Protect Plus antiseptic disinfectant, Izal® liquid germicide disinfectant, Ivy’s antiseptic®, Dettol® antiseptic disinfectant and a locally produced antiseptic. The test organisms used in this study were Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Campylobacter jejuni and Candida albicans. Agar well diffusion method was used to test the antibacterial activity of the various antiseptic/disinfectant at different concentrations (100%, 50% and 25%) as described by the Clinical and Laboratory Standards Institute. The results obtained from this study showed that the test organisms vary in their responses to each of the disinfectant, although all five pathogens were sensitive to Izal® and Roberts® antiseptic at different concentrations. On the other hand, Izal® and Tetmosol® Protect Plus gave the highest inhibition zone diameter (IZD) readings of 41mm and 33mm respectively against Klebsiella pneumoniae at 100% concentration while Ivy’s antiseptic® had no antimicrobial effect against Escherichia coli in all the different concentrations used. The locally produced disinfectant gave the highest inhibition zone diameter (IZD) readings for Candida albicans making it very suitable to be used as an antifungal agent. This study has revealed that the antimicrobial effects of antiseptics and disinfectants are dependent on their different concentrations and nature of microorganism. Therefore, emphasis should be made on the need for strict adherence to standard disinfection policy for proper use of disinfectants and antiseptics.

[Full Text Article]   [Download Certificate]