World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL FILM OF IVABRADINE HYDROCHLORIDE FOR ANGINA PECTORIS

Raut D. B.*, Chaudhari R. G.*, Burade K. B., Gavhane Y. N.

ABSTRACT

The objective of this study was to develop and evaluate mucoadhesive buccal film of Ivabradine hydrochloride using mucoadhesive polymer HPMC E5 LV for angina pectoris. During study polyvinylpyrrolidone considered as a thickening agent, film former. PEG 4000 and PEG 6000 use as a plasticizer as well as solubilizing agent. Tween 80 use as a permeation inhancer. A total number of six formulations were prepared by a solvent casting method. The prepared mucoadhesive film were evaluated for drug content, in-vitro dissolution, Ex Vivo Permeation folding endurance, mucoadhesive strength, swelling index, and drug-polymer interaction study. From the present study, it found that formulation F3 and F5 show in vitro drug release 94.08% ± 0.15, 98.51% ± .612 respectively within 3hr. Ex vivo drug permeation found to be 65.87% and 71.48% within 4 Hr. by using goat oral mucosa. There was no any physical and chemical interaction between drug and polymer based on physical and FTIR data interpretation.

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