World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

EVALUATION AND FORMULATION OF RIFAMPICIN TABLET

*Supriyadi and Widodo Priyanto

ABSTRACT

Rifampicin is a broad spectrum of an antibiotic and commonly used as a fire line therapy for Mycobacterium tuberculosis infection and is a first-line form of treatment for tuberculosis. Rifampicin tablets were made with the active ingredient of rifampicin, filler and disintegrant mixture of starch and lactose. The tablets exhibited good physical quality and dissolution. The physical properties and dissolution profile analysis of rifampicin tablets were done using DDSolver, WinSAAM, and Monolix software. Rifampicin tablet formula was made using the wet granulation method. The evaluation of the physical properties of rifampicin tablets was done by testing several parameters including hardness, friability, disintegration time, and dissolution. Dissolution profile results were analyzed using DDSolver software to determine the kinetics of drug release, WinSAAM to investigate the compartment model of conventional rifampicin tablets, and Monolix to determine the dissolution profile and rifampicin compartment model easily and practically using population-based approaches. The results showed that rifampicin tablets from the formula had a mixture of starch and lactose disintegrant was exhibit a have good physical quality and dissolution profile and meet the requirements of the Indonesian Pharmacopoeia thus, it has better efficacy.

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