Abstract
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF OXCARBAZEPINE USING DIFFERENT POLYMERS
Sadiya Firdouse*
ABSTRACT
The aim of present investigation was to formulate and evaluate the sustained release tablets of Oxcarbazepine. These matrix tablets were prepared by direct compression method using natural polymers like Aloes Powder,Gum copal, Gum dammar. In vitro drug release studies were performed by USP dissolution apparatus type II using 0.1N HCL buffer and 6.8 Phosphate buffer for 12hrs. Among all the 12 formulations Formulation F9 showed maximum drug release 99.53% for 12hrs study. It was observed from the kinetic studies that all the formulation followed Peppas-Release kinetics.
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